Here are three tips for Singaporean patients considering egg donation in Malaysia:
(1) Do not do highly-expensive genetic screening of IVF embryos (PGS / PGT-A). Instead, insist on doing genetic testing of the egg donor's blood sample, which is much cheaper than PGS. Moreover, you can also use NIPT (Non-Invasive Prenatal Testing) to screen for genetic defects in your unborn child after conception, which is also much cheaper than PGS.
A blood sample contains thousands of white blood cells, from which an abundant amount of DNA genetic material can be extracted. By contrast, only a few cells and tiny amount of DNA are extracted from the embryo during PGS (biopsy procedure). This makes it technically simpler and much cheaper to do genetic screening of the Egg Donor's blood sample, as compared to genetic screening of embryos with PGS / PGT-A.
(2) Use egg donors that reside locally within the same city as the IVF clinic. Avoid using traveling egg donors from out-of-town or out-of-state, who reside far away from the IVF clinic. It is much more difficult to control and monitor the ovarian stimulation cycle of traveling egg donors from out-of-town. If possible, insist that the egg donor regularly receives hormone injections (recorded) by a nurse at the IVF clinic itself.
Singaporean patients must beware that most egg donors in Johor come from out-of-town or out-of-state. This is because the overwhelming majority of egg donor agencies and agents in Malaysia are based in Kuala Lumpur and Penang, and IVF clinics in Johor rely on such agencies and agents to source egg donors for their patients.
It is common practice for doctors to hand over expensive hormone medications (requiring refrigeration) directly to out-of-town donors, and expect the donor to self-inject, maybe with some supervision from the agent.
Such out-of-town egg donors may commute to the clinic for medical appointments, receive the hormone medications and then return to their hometowns where they are expected to self-inject for several days. They will then commute again to Johor for further appointments to scan their follicles, or for the final egg-retrieval surgery.
Anyone who had undergone IVF can appreciate the painful and tedious procedure of self-injections. Without any direct supervision from the IVF clinic, the egg donor or agent may not be bothered to strictly comply with such a painful and tedious routine of self-injections. If they are extra careless, the expensive hormone medications may not be stored in the refrigerator, leading to spoilage and reduced potency. Without strict adherence to the injection protocol, the number and quality of eggs obtained from the donor will be severely compromised.
(3) When doing IVF with frozen (vitrified) donor eggs, use the same fertility clinic or IVF lab that recruited the egg donor and freeze her eggs. Avoid using frozen donor eggs that are transferred from an egg bank. If possible, use the IVF lab that is affiliated with that egg bank. For best results, the thawing protocol must be matching and compatible with the freezing (vitrification) protocol, and only the same IVF lab that performs both the freezing and thawing processes, can ensure this. Also beware that IVF success rates with frozen donor eggs are significantly lower than with fresh donor eggs.