2WW - for those TTC-ing

Pixie, let's start with talking abt a normal menstrual cycle. After ovulation, there is an increase in progesterone (Duphaston is a synthetic form of progesterone) to prepare for implantation. The corpus luteum is responsible for the increase in progesterone. If there is no implantation, the corpus luteum dies and the levels of progesterone and oestrogen drops. The uterine lining then breaks down, and you have your period. This is how you induce your period - By taking progesterone and then stopping it. What you are doing here is to use the duphaston to over-ride your own system if you get what I mean.

Progesterone is needed to maintain the uterine lining when you are pregnant. Remember the part on the corpus luteum from above? Initially it is the corpus luteum doing the job of producing progesterone. But after that, the placenta takes over the job :)

not really lei... i still confuse... when i just taking clomid, not trying IUI and was not prescribe duphaston, my menses will come CD30 naturally as per my normal cycle.

but because of IUI, i was prescribe duphaston for DPO 3 weeks... so it doesn't induce menses even im not pregnant.. if i keep taking it, my menses dun come. if i stop taking it, my menses will come. so even though i was prescribe for 3 weeks, i only took it for 2 weeks so that my menses would come after i test im not pregnant.

so u saying that taking duphaston is build your lining, then you stop taking duphaston, then you have lining to break down for menses? then maybe not applicable for me, because naturally i already have lining form every month.
 


Sorry for the abrupt interruption, can i just check w u ladies if u consider this a positive opk. I'm aldy on cd 28, super late ovulation, if any .. But i still pray i do.. Thanks in advance!
ImageUploadedByForum1435886730.114054.jpg
 
not really lei... i still confuse... when i just taking clomid, not trying IUI and was not prescribe duphaston, my menses will come CD30 naturally as per my normal cycle.

but because of IUI, i was prescribe duphaston for DPO 3 weeks... so it doesn't induce menses even im not pregnant.. if i keep taking it, my menses dun come. if i stop taking it, my menses will come. so even though i was prescribe for 3 weeks, i only took it for 2 weeks so that my menses would come after i test im not pregnant.

so u saying that taking duphaston is build your lining, then you stop taking duphaston, then you have lining to break down for menses? then maybe not applicable for me, because naturally i already have lining form every month.

Technically, when you use clomid, it is not an assisted conception and it is somewhat natural except for the medication which is used to increase your follicle quantity or sometimes, it can assist to increase follicle size too.

However, when you are doing IUI, it's an assisted conception. With assisted conception, gynae will usually prescribe duphaston. Duphaston is prescribed to support your progesterone level and continue to make your body think that it has high HCG to support potential pregnancy. Having said that, our body recognizes that once you stop duphaston, your body will be led to think that your corpeus luteum have not implanted well or didn't implant at all. So hence, you will start to have onset of AF.

Also, uterine lining is usually thickened once you have ovulated and corpeus luteum have been formed. Mainly duphaston increases/thickens your lining further.
 
Sorry for the abrupt interruption, can i just check w u ladies if u consider this a positive opk. I'm aldy on cd 28, super late ovulation, if any .. But i still pray i do.. Thanks in advance! View attachment 548713

It doesn't look like a positive opk though I think you are probably going to get positive soon. My suggestion is to test a few more times in the next 1-5 hours. If it gets as dark as control line, it is positive.
 
recently my colleague gave birth to a cute bb boy ....
now 3 of my friends are 9 mths+ and waiting to give birth any moment.
next month will be a busy month for me visiting around hahhaa ...

sometimes i have a mix feeling of envy and relieved ....
i would love to have kids, but at the same time worrying i cant cope .. haha such dilemma -- women

still havent received the call from clinic to get my report. supposed to be 1 week but its already 2 weeks!
dono shld continue to wait or call the clinic to ask ...

its friday! like finally!
 
not really lei... i still confuse... when i just taking clomid, not trying IUI and was not prescribe duphaston, my menses will come CD30 naturally as per my normal cycle.

but because of IUI, i was prescribe duphaston for DPO 3 weeks... so it doesn't induce menses even im not pregnant.. if i keep taking it, my menses dun come. if i stop taking it, my menses will come. so even though i was prescribe for 3 weeks, i only took it for 2 weeks so that my menses would come after i test im not pregnant.

so u saying that taking duphaston is build your lining, then you stop taking duphaston, then you have lining to break down for menses? then maybe not applicable for me, because naturally i already have lining form every month.
maybe u shld not view taking duphaston as the same as taking say, a laxative to make you sh**.i.e. taking the duphaston does not make your lining break down. Rather, it is the act of ceasing the intake of duphaston that causes the lining to break down. So, it's like your natural system is screwed, and it doesn't realize that it shld expel the excess lining. Hence, you take the duphaston to make your body think that it is time for the lining to be expelled.
 
Technically, when you use clomid, it is not an assisted conception and it is somewhat natural except for the medication which is used to increase your follicle quantity or sometimes, it can assist to increase follicle size too.

However, when you are doing IUI, it's an assisted conception. With assisted conception, gynae will usually prescribe duphaston. Duphaston is prescribed to support your progesterone level and continue to make your body think that it has high HCG to support potential pregnancy. Having said that, our body recognizes that once you stop duphaston, your body will be led to think that your corpeus luteum have not implanted well or didn't implant at all. So hence, you will start to have onset of AF.

Also, uterine lining is usually thickened once you have ovulated and corpeus luteum have been formed. Mainly duphaston increases/thickens your lining further.
Agreed with grace. With assisted reproductive techniques, typically medicines are given to override our own natural system. that said, I go back to the part on the corpus luteum again. when u are preggie, there is hcg. the hcg keeps the corpus luteum alive and thus it is able to produce progesterone :)
 
I hope so too. Do u feel tired aft ttc for a while..like every alt day during peak period supposed to increase chance but it become more like a chore...
Hmmm. Actually I only ttc last month. Eventually is not a bfp. So will try harder this month. So I'm not feeling the tiredness. Don't make yourself to feel it a tiredness or chore . It's a leisure when bd with hub. Even If not ttc also must have bd leisure with hub. If not the relationship will go wrongly.
 
Hi anyone tried clomid 50mg doesn't ovulate and gyn increase to 100mg and success?
My clomid @ 50mg didn't work cos I didn't get the LH surge after taking it (took it for 1 cycle). But I managed to strike abt 2mths after I finished that 5 tablets in the 1st cycle. My bfp was not from the clomid ..it was just like a random occurrence
 
Thanks @graceakaclouds and @gammahedging for the detailed information as well as kind support, now I understand how the medicine works :)

My first round of clomid gave me a LH Surge but we did not manage to gauge the time correctly due to some family problems, so yeah. Currently am on second cycle of 50mg, the gynae told me that I have to increase the dosage to 100mg next cycle to see if it helps on the follicles' size.

I am seeing Dr. SF Loh from TMC on Monday, I am gonna share what had happened and hopefully he can advise better what shall we do next.
 
My clomid @ 50mg didn't work cos I didn't get the LH surge after taking it (took it for 1 cycle). But I managed to strike abt 2mths after I finished that 5 tablets in the 1st cycle. My bfp was not from the clomid ..it was just like a random occurrence

Clomid sometimes works aft 1 or 2 mths.. thats according to 2 different gynaes I've seen..it might not work on the cycle u took.. depends on individual body systm..
Clomid works for me during my 2nd pregnancy, but the pregnancy ended as a molar pregnancy...
And the nex round of clomid I took, I got preg only aft 3 mths I finished the clomid cycle... but it ended with an ectopic pregnancy...
And now clomid doesnt work for me at all.. hahaha.. increased to 150mg, and I still couldn't ovulate...

So I did the iui and was on puregon jabs.. successful on our first iui try...but it ended at 8 weeks, Blighted Ovum...
I just dont have the luck lah.. hehehe
 
Technically, when you use clomid, it is not an assisted conception and it is somewhat natural except for the medication which is used to increase your follicle quantity or sometimes, it can assist to increase follicle size too.

However, when you are doing IUI, it's an assisted conception. With assisted conception, gynae will usually prescribe duphaston. Duphaston is prescribed to support your progesterone level and continue to make your body think that it has high HCG to support potential pregnancy. Having said that, our body recognizes that once you stop duphaston, your body will be led to think that your corpeus luteum have not implanted well or didn't implant at all. So hence, you will start to have onset of AF.

Also, uterine lining is usually thickened once you have ovulated and corpeus luteum have been formed. Mainly duphaston increases/thickens your lining further.

yupz.. that why i said duphaston does not induce menses for me. only delay menses for me. so in order not to waste time, i dont complete 3 weeks course... coz if im not pregnant, then no point taking it

so in case anyone need extra duphaston, can take from me :p
 
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maybe u shld not view taking duphaston as the same as taking say, a laxative to make you sh**.i.e. taking the duphaston does not make your lining break down. Rather, it is the act of ceasing the intake of duphaston that causes the lining to break down. So, it's like your natural system is screwed, and it doesn't realize that it shld expel the excess lining. Hence, you take the duphaston to make your body think that it is time for the lining to be expelled.

errr.. but my case duphaston does not mkae my body think it is time for the lining to be expelled.... it will keep on injecting progesterone and build up the lining and delaying my menses.
anyway i dun need a medicine to induce menses, because it will confirm come on CD29... hence i will stop taking it so that my menses will come...
 
Thanks @graceakaclouds and @gammahedging for the detailed information as well as kind support, now I understand how the medicine works :)

My first round of clomid gave me a LH Surge but we did not manage to gauge the time correctly due to some family problems, so yeah. Currently am on second cycle of 50mg, the gynae told me that I have to increase the dosage to 100mg next cycle to see if it helps on the follicles' size.

I am seeing Dr. SF Loh from TMC on Monday, I am gonna share what had happened and hopefully he can advise better what shall we do next.

Did your previous gynae measure your follicle size when you went back for review? Usually they will follow closely to see if your follicle is growing well. Ideally, to become a corpus luteum, your follicle will need to grow to a minimum 22mm. If with clomid you don't have sufficient growth, your gynae might have to opt for a different med/jab.

Personally, I took 50mg clomid for 3 months without much success. Thereafter, I took 100mg ovamit (another form of clomid) for 1 month) without much success too. Follicle only grew about 3mm for a span of 5 days whilst I'm taking ovamit. So in the end, the gynae changed the route to jabs instead and follicles grew more as well as in size too.
 
Ideally, to become a corpus luteum, your follicle will need to grow to a minimum 22mm. If with clomid you don't have sufficient growth, your gynae might have to opt for a different med/jab.
need to be so big?!!?
coz my gynae told me 17mm is enough.... mine is IUI, so always gt 3 follicles.. 14mm to 23mm on CD10... then CD11 do trigger shot.. then CD13 do IUI

if need to be bigger, should i tell my gynae to delay another few days to let it grow bigger?

or maybe tat is the reason why my IUI keep failing coz follicles not big enough?
 
Did your previous gynae measure your follicle size when you went back for review? Usually they will follow closely to see if your follicle is growing well. Ideally, to become a corpus luteum, your follicle will need to grow to a minimum 22mm. If with clomid you don't have sufficient growth, your gynae might have to opt for a different med/jab.

Personally, I took 50mg clomid for 3 months without much success. Thereafter, I took 100mg ovamit (another form of clomid) for 1 month) without much success too. Follicle only grew about 3mm for a span of 5 days whilst I'm taking ovamit. So in the end, the gynae changed the route to jabs instead and follicles grew more as well as in size too.

Yeah she did.

I had ultrasound scan on CD13 and the biggest follicles only measured at 10mm, which is only half of the ideal size. That was why she failed me on the spot by telling me that "Ok, we know you'll be out and not getting pregnant for sure this month".

I suspect ovulation did not happen this cycle due to the insufficient size of follicles.

She said I have to increase the dosage to 100mg next cycle.

By the way, do you mind sharing on which days did you have your clomid? My gynae asked me to take from CD2 onwards but I've seen some ladies starting on CD3 or CD5.
 
need to be so big?!!?
coz my gynae told me 17mm is enough.... mine is IUI, so always gt 3 follicles.. 14mm to 23mm on CD10... then CD11 do trigger shot.. then CD13 do IUI

if need to be bigger, should i tell my gynae to delay another few days to let it grow bigger?

or maybe tat is the reason why my IUI keep failing coz follicles not big enough?

My gynae is a fertility specialist so his criteria could be different. Technically, gynae and fertility specialist have diff requirements for both female and males. For gynae, maybe 17mm is sufficient but for fertility specialist, at least 22mm bah. But I rem asking him before, he said ideally 22mm would be a good size to turn into corpeus luteum.
 
Yeah she did.

I had ultrasound scan on CD13 and the biggest follicles only measured at 10mm, which is only half of the ideal size. That was why she failed me on the spot by telling me that "Ok, we know you'll be out and not getting pregnant for sure this month".

I suspect ovulation did not happen this cycle due to the insufficient size of follicles.

She said I have to increase the dosage to 100mg next cycle.

By the way, do you mind sharing on which days did you have your clomid? My gynae asked me to take from CD2 onwards but I've seen some ladies starting on CD3 or CD5.

Yes your gynae is right. We are looking at the ideal cycle of 28 days where ovulation will take place ideally on cd14. That would be that by cd14, your follicle needs to be 22mm thereabout. You have the same issue as me. For me, by cd13, it is only max 11m or 13mm at most. Definitely won't grow sufficiently in time.

Another way your gynae will try is to increase dosage of clomid, change med or just do jabs instead. For mine, after clomid and ovamit for 4 months, it just didn't work. So my gynae said let's not waste time. To be honest, oral med has lesser effect than jabs but of course, jabs will be more expensive and whether your gynae wants to administer them on you, it would be another issue.

I took clomid from cd2 to cd7. As for ovamit, I took from cd3 to cd8. Technically, if you took it earlier like on cd2, your follicles should multiply/grow bigger in size by cd13. Perhaps you might want to check with your gynae if clomid doesn't work for you, what is the next backup plan?
 
My gynae is a fertility specialist so his criteria could be different. Technically, gynae and fertility specialist have diff requirements for both female and males. For gynae, maybe 17mm is sufficient but for fertility specialist, at least 22mm bah. But I rem asking him before, he said ideally 22mm would be a good size to turn into corpeus luteum.
err... mine is Consultant Obstetrician & Gynaecologist, Fertility Specialist
so is both?
but he told me 17mm is sufficient...
 
Clomid sometimes works aft 1 or 2 mths.. thats according to 2 different gynaes I've seen..it might not work on the cycle u took.. depends on individual body systm..
Clomid works for me during my 2nd pregnancy, but the pregnancy ended as a molar pregnancy...
And the nex round of clomid I took, I got preg only aft 3 mths I finished the clomid cycle... but it ended with an ectopic pregnancy...
And now clomid doesnt work for me at all.. hahaha.. increased to 150mg, and I still couldn't ovulate...

So I did the iui and was on puregon jabs.. successful on our first iui try...but it ended at 8 weeks, Blighted Ovum...
I just dont have the luck lah.. hehehe
i didn't know that for some people, it takes 1-2 mths upon finishing the 5 tablets to ovulate? my gynae told me that it may well be possible that the clomid didn't work on me after I asked him why I don't see an LH surge 2 wks after I finished the last tablet. I was waiting for my period to come some more -_- waited and waited, but it nv came. but I went to test because a. I had very painful (.)(.) for 2 weeks and b. it was close to 3 mths since I had my last period. if not preggie, then I can ask for medicine to induce my period. and then I found myself 2-3 wks preggie
 
Yeah she did.

I had ultrasound scan on CD13 and the biggest follicles only measured at 10mm, which is only half of the ideal size. That was why she failed me on the spot by telling me that "Ok, we know you'll be out and not getting pregnant for sure this month".

I suspect ovulation did not happen this cycle due to the insufficient size of follicles.

She said I have to increase the dosage to 100mg next cycle.

By the way, do you mind sharing on which days did you have your clomid? My gynae asked me to take from CD2 onwards but I've seen some ladies starting on CD3 or CD5.
iirc I took my clomid on cd 5 or 6. as long as the uterine lining is still thin, it's ok
 
Yes your gynae is right. We are looking at the ideal cycle of 28 days where ovulation will take place ideally on cd14. That would be that by cd14, your follicle needs to be 22mm thereabout. You have the same issue as me. For me, by cd13, it is only max 11m or 13mm at most. Definitely won't grow sufficiently in time.

Another way your gynae will try is to increase dosage of clomid, change med or just do jabs instead. For mine, after clomid and ovamit for 4 months, it just didn't work. So my gynae said let's not waste time. To be honest, oral med has lesser effect than jabs but of course, jabs will be more expensive and whether your gynae wants to administer them on you, it would be another issue.

I took clomid from cd2 to cd7. As for ovamit, I took from cd3 to cd8. Technically, if you took it earlier like on cd2, your follicles should multiply/grow bigger in size by cd13. Perhaps you might want to check with your gynae if clomid doesn't work for you, what is the next backup plan?

I see. So now I gained new knowledge again :)
Thanks babe!

I did talk to her on this but what she told me was "Don't worry so much now. We will talk about it again by then" and did not really give me an idea on what's the next plan. All I need to do is just to wait, she said.
 
Hi, just want to share, regarding follicle size....
My tcm advised me to eat egg white before ovulation and my follicle did increase from 12mm to 22mm within a few days. Hope that helps!

Thanks dear for sharing!

May I know if there's any specific quantity to be consumed? And when to start? It might be challenging for those whose cycles are not very regular.
 
Follicle size can trigger when it is minimum 17mm. 22mm it's too big cos when U trigger it will still grow before the egg is out. In Ivf we always do egg retrieval when follicle size hit 18 to 20mm. 17 is ok too. Too big the egg will be too old n too mature.
Yes find fertlilty dr rather than a normal gynae. Fertility dr is more experience in TTC. Normal gynae just do the general thing n their experience more towards pregnant lady.
 
need to be so big?!!?
coz my gynae told me 17mm is enough.... mine is IUI, so always gt 3 follicles.. 14mm to 23mm on CD10... then CD11 do trigger shot.. then CD13 do IUI

if need to be bigger, should i tell my gynae to delay another few days to let it grow bigger?

or maybe tat is the reason why my IUI keep failing coz follicles not big enough?

There are many reason why iui don't work. It could be timing issue, egg shell too hard or egg quality. If U delay in trigger your 23mm may have to forgo cos it will be too mature n what if your 14mm cannot catchup n still immature.
 
There are many reason why iui don't work. It could be timing issue, egg shell too hard or egg quality. If U delay in trigger your 23mm may have to forgo cos it will be too mature n what if your 14mm cannot catchup n still immature.
Is there a specific size of follicles to have a mature egg. How do you know the egg is mature not?
 
I am sorry to hear that.
Having AF doesn't mean one is ovulating, it can happen every month even though one is not ovulating regularly.
After removing fibroid etc.. recently den we start our b project again. After i heard nasty comments from his auntie which i felt sooo depresss.. so this round work harder..

So i bought that cb ovulation kit and test.that time when i tested the o kit. Almost everyday den i found out i dont ovulate. Den i went back to kkh and tell the doc. He gave me letrozole for 3 mths. Ask me the 1st doze 21day went back for blood test. Now i m on the 2nd doze.. tested this mth ovulate den ask my hub bd. Then my doc tell me tat he is transferring out of kkh.. haiz..
 
Is there a specific size of follicles to have a mature egg. How do you know the egg is mature not?
Won't know unless you do ivf. Follicles may be just fluid inside with no egg. And with ivf, retrieved eggs may not be fertilised also.
 
Yup varine is right. We won't know till eggs are being extract out. Follicles can be empty without eggs. Generally by 17mm should mature but some ppl have to reach 18mm.
 
@veraine & @Jumbo girl,
If there is no egg will you still have menses regularly? From what you all say are getting me worried. Worrying will I have mature egg in me.
Yup.. Menses may still occur regularly.. Even for a healthy fertile woman, she may not be producing an egg every single cycle .. So don't worry too much abt it

Creating life is a miracle.. Cos there're just too many variables to affect the possibility of it

Start worrying only when you've tried for many months and still not getting bfp?
 
Yup.. Menses may still occur regularly.. Even for a healthy fertile woman, she may not be producing an egg every single cycle .. So don't worry too much abt it

Creating life is a miracle.. Cos there're just too many variables to affect the possibility of it

Start worrying only when you've tried for many months and still not getting bfp?
If there is a opk positive means producing an egg?
 
If there is a opk positive means producing an egg?
No also, it just means your body has produced a larger amount of LH at that point of time, which would result in the rupturing of a follicle (for most women). But if the follicle ruptures, it may not have any egg inside.

I have PCOS, and I have clear positives on opk and distinct temp diff to indicate luteal phase, but going by u/s scans, ovulation did not take place
 
No also, it just means your body has produced a larger amount of LH at that point of time, which would result in the rupturing of a follicle (for most women). But if the follicle ruptures, it may not have any egg inside.

I have PCOS, and I have clear positives on opk and distinct temp diff to indicate luteal phase, but going by u/s scans, ovulation did not take place
How long have you been ttc when you when for the scan?
 
How long have you been ttc when you when for the scan?
Slightly over a year of active TTC then went to see a gynae

Mine obviously was PCOS, so started having treatments.. Otherwise most docs would prob ask you to be patient and continue trying
 
If there is a opk positive means producing an egg?
Opk positive only tells U that your LH surge and not necessary will ovulate. If you have been trying every mth for one yr and still no result it is best to see a fertility specialist. There are many factors to BFP. Egg must be healthy, sperm count good, tube not block, no other womb scarring or antibody. Even if all the above is good the sperm must also meet the egg and able to fertilise it. Don't worry too much many ladies do succeed after trying a yr. however don't drag too long to seek help. Age is impt in any treatment.

Pcos means polycystic ovary syndrome.
 
Thanks dear for sharing!

May I know if there's any specific quantity to be consumed? And when to start? It might be challenging for those whose cycles are not very regular.

I think one should eat one egg white a day from day 12/13. However, as I didn't know about this, I ate them at day 14 and day 15. I did iui on day 17.
 
Hi im new here.. I took clomid 50mg for 2nd cycle and afta 21days I was asked to go for blood test. May I know what the blood test for? Bcoz the nurse call me and said that my blood test gd..thats mean I can high chance get pregnant this cycle? Im kinda lost and confused..
 


told myself i wouldn't symptom spot but the light cramps are constantly there, can't help but to think about it.
had light pinching sensation in one particular spot on and off yesterday

the 2ww is just too long.
 

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